The Effects of soy isoflavones and risk of breast cancer

  • سال انتشار: 1391
  • محل انتشار: هشتمین کنگره بین المللی سرطان پستان
  • کد COI اختصاصی: ICBCMED08_153
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 358
دانلود فایل این مقاله

نویسندگان

kk safariasl

Department of Food Science and Nutrition shahid Beheshti University of Medical Sciences

چکیده

Background:Breast cancer is one of the commonest cancers in women at theworldwide. The incidence of cancer, particularly at ages 40 to 60 years and hasthe second grade between the ages of 30 to 40. The probability of risk is one pereight women. Soybeans have isoflavones named daidzein and genistein that areweak estrogens. This review aims the role of phytoestrogen and soya rich foodconsumption for the prevention of breast cancer.Materials and methods : In this study contents were collected the range ofyears 2005 – 2012 from the googleschoolar, iranmedex ,sciencedirect ,pubmedsites.Results:Studies have proven that soy products prevent the incidence of cancersbecause of the phytoestrogen. Daily consumption of soy-rich diet compared todomestic diet decrease the level of 17-β estadiol in amount of 25% andprogestron in amount of 45%. Most studies had done with genistein that have acombination of agonist – antagonist effect on estrogen-sensitive cells. Treatingwith genistein stimulates TGF-α to increase the differentiation of the mammarygland. Tumors treated with higher dosage of soy extract was consideredstatistically significant.Conclusion:One of the effecting mechanisms of soybean isoflavones indecreasing the risk of breast cancer is the impact on sex hormone levels andmenstrual cycle of androgens. Pytoestrogens stimulate the production of SHBG(Sex hormone binding proteins) in liver cells, decrease the level of sexhormones and can stretch out menstrual cycle. Consumption of soy productsand genistein extract are as adjective treatment . Although Further studies isneeded to clarify the effect of soy consumption in the prevention of breast cance

کلیدواژه ها

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.