Chronic inflammation leads ASD children to Cancer
- سال انتشار: 1396
- محل انتشار: هفتمین همایش بیوانفورماتیک ایران
- کد COI اختصاصی: IBIS07_024
- زبان مقاله: انگلیسی
- تعداد مشاهده: 577
نویسندگان
Molecular R&D section, Masir-e-Sabz clinic, Tehran, Iran
Molecular R&D section, Masir-e-Sabz clinic, Tehran, Iran
Molecular R&D section, Masir-e-Sabz clinic, Tehran, Iran
Molecular R&D section, Masir-e-Sabz clinic, Tehran, Iran
چکیده
Autism spectrum disorders (ASDs) are characterized by deficit in ability of Social cognition, emotions and illustrating repetitive behavior [3]. In recent neuropathology studies on children with ASD resolved that there is continues neuroinflammation in their central nerves system (CNS). Furthermore, multi-omic studies proved that ASD and cancer share common genes and molecular mechanisms [1]. Cancer is a complex heterogeneous disease in which a genetic mutation leads to uncontrolled proliferation of the cells. Inflammation is one of the defensive mechanisms against pathogens and establishing tissue homeostasis. Inflammation is also a cancer hallmark, and chronic inflammation have been demonstrated in 25% of cancers. Inflammation contributes to cancer progression and metastasis by creating appropriate conditions such as activating the NFkB signaling pathways and producing inflammatory mediators [2]. Our suggestion is that chronic inflammation increases the risk of cancer in individuals diagnosed with ASDکلیدواژه ها
Autism; Cancer; Inflammation; NF-Kbاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.