Meta-Analysis Approach to the Estrogen Receptor-Alpha Gene PvuII (T/C) Polymorphism and Preeclampsia Risk

  • سال انتشار: 1396
  • محل انتشار: هفتمین همایش بیوانفورماتیک ایران
  • کد COI اختصاصی: IBIS07_020
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 497
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نویسندگان

Ali Taravati

Department of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran

Mojtaba Hassani

Department of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran

چکیده

Several studies have been reported the association between estrogen receptor α (ESR1) gene polymorphisms and various pathological conditions, including pre-eclampsia. The present meta-analysis was done to elucidate the association of PvuII (T/C) polymorphism with pre-eclampsia among pregnant women. A literature search was conducted in electronic databases including PubMed, Scopus, Elsevier, Springer and Google Scholar to find eligible studies. The pooled odds ratios (ORs) with 95% confidence intervals were calculated under dominant, recessive, co-dominant, and allelic models. This meta-analysis included 4 eligible studies consisting 612 cases and 619 controls. The ORs for the PvuII (T/C) polymorphism and pre-eclampsia were not indicative of any association under several genetic models including dominant model (CC+CT vs. TT: OR = 1.106 [95%CI: 0.851–1.436]; p = 0.452), recessive model (CC vs. CT+TT: OR =1.028 [95%CI: 0.793–1.334]; p = 0.833), co-dominant model (CC vs. TT: OR = 1.094 [95%CI: 0.791–1.513]; p = 0.014), and allelic model (C vs. T: OR = 1.051 [95%CI: 0.897–1.233]; p = 0.538). In summary, PvuII (T/C) polymorphism has not significant association with the risk of pre-eclampsia among pregnant women. It could be of value to investigate its association with pre-eclampsia in combination with additional risk factors. However, very large studies with different ethnic population are required to accurately demonstrate the role of this candidate gene in development of pre-eclampsia

کلیدواژه ها

Pre-eclampsia; Estrogen Receptor-Alpha; PvuII (T/C); Meta-analysis

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