The role of pharmacogenomics in chemotherapeutic cardiotoxicity
محل انتشار: سومین سمپوزیوم بین المللی سرطان نسترن
سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 519
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شناسه ملی سند علمی:
NASTARANCANSER03_212
تاریخ نمایه سازی: 7 اسفند 1396
چکیده مقاله:
Several effective and common prescribed adjuvant therapies may present toxicities for many years. Among these, cardiotoxic drugs such as doxorubicin, trastuzumab and paclitaxel, have toxic effects onthe structure or function of the cardiovascular system. It is believed that genetic differences may responsible for why certain patients experience cardiotoxicity while others can tolerate high chemotherapy doses. We aimed to discuss the role of genetic variation on the cardiotoxic drugs. PubMed and Scopus databases have been searched based on all relative papers published from 1984 up to date. Keywords were selected as Cardiotoxicity, Chemotherapy and pharmacogenomics. Although several studies demonstrated genetic variations associated with the clinical outcome due to chemotherapy but in small sample sizes, inhomogeneous patient cohorts, nonsystematic genetic analysis, and mostly lacked any functional validation. Several pharmacogenomics researches adapting both candidate genetic variants and genome wide approaches have tried and in part succeeded in the detection of genetic variants associated with cardiotoxicity such as ABCC5, UGT1A6, CBR3, RAC2, CYBA, RARG. Considering all these facts, it is believed that a comprehensive whole genome analysis based on wide genome genotyping will be valuable and provide functional mechanistic proof for the involvement of candidate genetic variations in genotype testing before cancer chemotherapy
کلیدواژه ها:
نویسندگان
Najmeh Ahangari
Department Of Modern Sciences And Technologies, Faculty Of Medicine, Mashhad University Of Medical Sciences, Mashhad, Iran
Forouzan Amerizadeh
Department Of Modern Sciences And Technologies, Faculty Of Medicine, Mashhad University Of Medical Sciences, Mashhad, Iran
Majid Ghayour Mobarhan
Department Of Modern Sciences And Technologies, Faculty Of Medicine, Mashhad University Of Medical Sciences, Mashhad, Iran
Alireza Pasdar
Department Of Modern Sciences And Technologies, Faculty Of Medicine, Mashhad University Of Medical Sciences, Mashhad, Iran