An in-silico expression assay of the MAGE family in malignances

Structural analysis and expression evaluation of the cell surface specific antigens of malignances could beproviding new molecular approaches for diagnosis and target therapy of cancers. In this regard, MAGEfamily with 25 known members and specific expression on the surface of cancerous cells provided apromising perspective for these aims. Bearing in mind, an in-silico expression of these antigens on thecell surface of 20 type of common cancerous and normal tissues were assessment and equilibrated viaversion 21 of SPSS. On the other hand, topology structures of the antigens were modeled on the surfaceof the cancerous cells. Moreover, the binding affinity of the selected antigen with corresponding ligandswas assessment via molecular docking process. The results of this study led to revealed the differentexpression of these antigens on the surface of cancers. However, the MAGE-A4 showed the highestexpression in the head and neck cancer. Moreover, topology features of this antigen leading to providedseveral oligopeptides with expression capacity on the surface of cancerous cells with connected to HLAfamily.In general, the results of this study in addition to detection the expression rate of MAGE familyantigens on the surface of cancerous and non-cancerous cells, led to presented the in-silico modelingexpression of MAGE-A4 antigen on the surface of cancerous cells for the first time.

کلیدواژه ها:

Cancer ، Antigen ، MAGE ، Docking ، Modeling