A Reviewon Chemical stabilizationmethods of collagen

سال انتشار: 1395
محل انتشار: چهاردهمین همایش بیوشیمی فیزیک ایران
کد COI اختصاصی: CBC14_023
زبان مقاله: انگلیسی
تعداد مشاهده: 538

نویسندگان

Department of Conservation of Cultural and Historic Objects, Art University of Isfahan, Isfahan, Iran

Organic Polymer Chemistry Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan, Iran- Nanotechnology and Advanced Materials Institute, Isfahan University of Technology, Isfahan, Iran- Center of Excellence in Sensors and

Hossein Ahmadi

Department of Conservation of Cultural and Historic Objects, Art University of Isfahan, Isfahan, Iran

چکیده

Collagen is an important biomaterial finding several applications as prosthesis, artificial tissue, drugcarrier and cosmetics [1].Generally, the isolated collagen from skin or tendon exhibits poor thermalstability, mechanical strength and water resistance, due to the destruction of natural cross-linking andassembly structure by neutral salt, acid, alkali, or proteases during the extraction process [2].Therefore,they are often modified for practical uses by various methods. Generally, methods applied to stabilizecollageninclude chemical crosslinking and/or physical treatments (dehydrothermal, radiation). Chemicalreactions are favored by the largenumber of collagen functional side groups [3]. This can be achieved by anumber of different cross-linking agents that react with specific amino acid residues on the collagenmolecule imparting individual biochemical, thermal and mechanical characteristics to thebiomaterial.Actually stabilizationof collagen reduces itsantigenicity and the rate of biodegradation andimproves thethermal and mechanical stability [4].The interaction of these agents may occur with the ε-amino group of lysine residues, the carboxyl groups of glutamic and aspartic acids, or with hydroxylgroups [5].Accordingly, in this paper we review and classify chemical stabilization methods and crosslinkingagents for collagen.

کلیدواژه ها

Biomaterial; Collagen; Amino acid; Modification;Stabilisation; Chemical cross-linking

مقالات مرتبط جدید

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.