Study On Cytotoxic Action Of Schiff Base Manganese (II) Complex

Cancer is the name given to a collection of related diseases. In all types of cancer, some of the body’scells begin to divide without stopping and spread into surrounding tissues. The Schiff basecomplexes have been used in catalytic reactions and as models for biological systems. This may beattributed to their stability, biological activity. Schiff base form an important class of organiccompounds with a wide variety of biological properties. Many studies have been reported regardingthe biological activities of Schiff bases, including their anticancer, antifungal, antibacterial, andherbicidal activities. Previous studies have shown that the synthesized complexes of some metalshave various effects such as anti-cancer properties. The survey was conducted to investigate theantiproliferative effects of Mn2+ complex of the N -N1 dipirodixol-1- 2 diaminobenzene schiff base.The Tubo cells were exposed with various concentrations (62.5, 125, 250, 500, 1000 μg/ml) of desiredschiff base and their morphological changes are examined using an inverted microscope. MTT assaywas conducted for evaluation of anti-proliferative properties of this compound. The viability ofTubo cells was suppressed with dose-dependent manner (IC50 about 62.5 μg/ml). Morphologicalchanges such as decrease volume of cells, changes in the shape (cell shrinkage) and reduction in thesize was observed in treated cells. The Mn2+ complex of N -N1 dipirodixol-1- 2 diaminobenzeneschiff base showed antiproliferative activity on tubo cells and induced apoptosis in these cells whichreveals anti- cancer properties of this compound.