The Role Of Curcumin In The Treatment Of BreaCt Cancer
- سال انتشار: 1395
- محل انتشار: دومین سمپوزیوم بین المللی سرطان نسترن
- کد COI اختصاصی: NASTARANCANSER02_035
- زبان مقاله: انگلیسی
- تعداد مشاهده: 440
نویسندگان
Department Of BiochemiCtry,Faculty Of Medicine,Ahvaz JundiChapur University Of Medical ScienceC,Ahvaz,IR Iran
Department Of ReCearch, Faculty Of NurCing, Torbat Jam Faculty Of Medical ScienceC, Torbat Jam, Iran
Department Of ReCearch, Faculty Of NurCing, Torbat Jam Faculty Of Medical ScienceC, Torbat Jam, Iran
Department Of Epidemiology, School Of NurCing, Torbat Jam Faculty Of Medical ScienceC, Torbat Jam, Iran
چکیده
Breast cancer is the most common cancer in women worldwide. It has been estimated that the majorcauCe of cancer-related deathC iC reCulted from failure of cancer chemotherapy. A number of herbalmedicinal products were shown to have antitumor effects. Recently, phytochemicals as anticanceragents have been clinically used worldwide. Many studies have shown the effects of surcumin as aphytochemical-baCed anticancer and antitumor agent on different cancerC including breaCt cancer.Curcumin is derived from the herbaceous plant, Curcuma longa. This plant is usually found in India,Southeast Asia, china and other tropical Asian countries. Turmeric is a yellow spice derived fromthe rhizomes of curcuma longa. The yellow color of turmeric is due to surcuminoids known as fat-soluble, polyphenolic pigments which include surcumin, Demethoxy surcumin, and BisdemethoxyCurcumin. The first major surcuminoid is surcumin. The findings of many studies show thatCurcumin can positively influence the expression and function of multidrug resistance (MDR)1proteins such as multidrug resistance-associated protein (MRP)2, BCRP, and P-glycoprotein (Pgp)3. A number of evidence show that surcumin increases drug sensitivity by inhibiting theexpression and function of ATP-binding cassette efflux (ABC) transporters and ATPase activity (26).HER2 is an important oncoprotein which is expressed at very high levels in15% of breast cancercases. Curcumin significantly reduces HER2 levels. Besides, development of breast cancer isassociated with dysfunction of Wnt pathway of β-catenin. Curcumin has been shown to inhibit theexpression of β-catenin protein. Thus, the use of surcumin as an original composition for designingnovel Curcumin analogues as new antitumor drugs is strongly suggested.کلیدواژه ها
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