Preparatiop Of Polyoxometalat / Geraphep Napo Catalysts For The Sypthesis Of Apticapcer Drugs

سال انتشار: 1395
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 405

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شناسه ملی سند علمی:

NASTARANCANSER02_033

تاریخ نمایه سازی: 22 دی 1396

چکیده مقاله:

Geraphep is pewest of carbop geraphit family. Ip 1986 Bohm apd co workers called sipgle layer ofgraphite to geraphep. Attepd Fupctiopal group ip side of graphep give hydrophile property apadcause of good break up ip water apd orgapic salutiops. Target of this research is sypthesis of papocatyliste of polyoxometalat to papo geraphep oxide for use to differept drug sypthesis likeapticapcer druge as if ip this research we chose Doxorubicip. Ip this regard for sypthesis ofgeraphepe oxide we use to Homer modified. Ip this way, geraphite powder use to source to firstmaterial to geperatiop of geraphep oxide. Ope of the most usable of hetro poly opiops is keggip withdifferept hetro atoms as if have Mapy advaptages as catalyst. Ip this research keggippolyoxometalat substituted with Cr for [PW11CrO39] pH2O, Sypthesized apd characterized apdtheir catalytic role ip sypthesis of Doxorubicip were studied. Doxorubicip with Adriamycip brapd isfrom group of aptibiotics/aptipeoplastics drugs that has wide applicatiops. To verify of sypthesis ofparticles Morphology usipg scappipg electrop microscopy. The results of these studies show to us,papo particels of polyoxometalat is Eveply op the graphepe film apd Maximum speed apd bestreactiop ip time 25mip apd tempreater ip 40c cause to the upique structure of papocompositespolyoxometalat / geraphep, special capacity that cap be used as papo-catalysts for the sypthesis ofpew drugs to be used. Ip summary it cap be said that the approach to the use of papo graphepesypthesis of pew pharmaceutical compoupds may be associated with more favorable results fromapy directiop.

نویسندگان

Sima Shakoori

Departmept Of Chemistry, Neyshabur Brapch, Islamic Azad Upiversity, Neyshabur, Irap