Synthesis of new derivatives of benzo[F]chromene with the potential COX-2 inhibitory effects

Highly efficient protocol for the synthesis of derivatives of benzo[F] chromene has been developed by one pot three component coupling of β-naphtol, 4-Thiomethylbenzaldehyde, Acetylacetone in ethanol in the presence of catalytic amounts of SnCl2 , Dabco, I2/K2CO3, Na2CO3,…under reflux conditions at 90ºC for 48 hrs.Then the mixture was purified by chromatography using ethyl acetate and n-hexane as eluent, which afforded the desired product in excellent purity. The molecular modeling studies of these derivatives were performed using Vina and Autodock-3 software.Finally the structures of molecules have been confirmed by, IR, 1HNMR and 13CNMR sprectroscopy.

کلیدواژه ها:

benzo[F]chromene derivatives ، β-naphtol ، multicomponent reactions ، one pot