MAJD HAJT HOSSETNT - Nuclear Fuel Cycle Research School, Nuclear Science de Technology Research, Atomic Energy Organization of Iran, Tehran, Iran
NAADER ALIZADEH - Department of Chemistry, Faculty of Basic Science, Tarbiat Modares University, P.O. Box۱۴۱۱۵-۱۷۵, Tehran, Iran
ALI REZA KHANCHI - Nuclear Fuel Cycle Research School, Nuclear Science & Technology Research, Atomic Energy Organization of Iran, Tehran, Iran

The aim of the present work was to prepare nanoparticles suspension by ultrasound waves in antisolvent precipitation system for enhancing availability of azithromycin (AZ) a poorly water-soluble drug. Use of high stream velocities enhances mixing of AZ ethanolic solution with water, whereas addition of polymers/surfactants inhibits/lowers the particle growth, was prepared a homogeneous solution. With ultrasound waves, phase transition was occurred and the AZ particles with size <100 nm was prepared. Several experimental parameters, such as the ratio of AZ to stabilizer, the type of stabilizer and the concentration of stabilizer, were investigated in the ethanol- deionized water system. The results showed that the best stabilizer is PVP (poly N-vinyl-2-pyrrolidone) 1 mg/ml that the produced nanosuspension had a mean particle size of 96 nm and size distribution 35- 200 m.

Azithromycin, Nanoparticle, Ultrasound, Antisolvent, Precipitation, phase transition