Rapid and Mild Synthesis of 5-Pyrimidinecarbonitriles by Using a TiO2-CNTs Nanocomposite Catalyst under Solvent-Free Conditions

The utilities of nanoscale metal oxide as heterogeneous catalyst occupy an interesting position in organic reactions owing to their special features such as high surface area and pore sizes as supports [1-2]. Among transition-metal oxide nanoparticles, nanosized titanium dioxide (TiO2 NPs) have been of considerable interest because of their superior properties such as high catalytic activity, non-toxicity, easily availability, moisture stability and reusability [3]. Moreover, carbon nanotubes (CNTs) as a support can be used to obtain nanoparticles with modified morphology, structural, chemical, electrical, and optical properties. The catalytic activity of titanium dioxide supported on carbon nanotubeshas been greatly improved [4]. Pyrimidines and their derivatives are of considerable interest as they possess a wide range of biological properties, such as antibacterial [5], antimicrobial [6], antiviral [7], antihypertensive [8], antimalarial [9], and antitumor [10].

کلیدواژه ها:

Environment-friendly procedure ، 5-Pyrimidinecarbonitriles ، Solvent-free conditions ، TiO2-CNTs nanocomposite