Kaveh Haddadi - Assistant Professor, Department of Neurosurgery, Imam Khomeini hospital, Orthopedic Research Center,Mazandaran University Of Medical Sciences, Sari, Mazandaran, Iran

Background & Aim: Low back pain is broadly documented as one of the most widespread pathologies in the advanceddomain. Although the reasons of low back pain are uncountable, it has been meaningfully related to intervertebral discdegeneration. Present therapies for Intervertebral Disc (IVD) degeneration such as physical therapy and spinal fusionreduce symptoms severity, but do not treat the source of degeneration. The use of tissue engineering to treat discdegeneration offers a chance to control the pathological course. New methods are presently being examined and haveexposed mixed results. One major way of study has been stem cell injections. We go on to define the course of stemcell-mediated modalities in treatment of degenerative lumbar disc herniationMethods & Materials/Patients: Literature search was performed in electronic databases PUBMED and EMBASEby means of Mesh terminologies (Nucleus pulposus, therapeutics, annulus fibrosus, intervertebral disc) and keywords(Degenerative disk disease, Stem Cells, Therapy).Results: The intervertebral disc organization, developing treatments, mesenchymal stem cells, embryonic stem cells,practice in disc degeneration were some sections that were found in analysis for study review design.Conclusion: Mesenchymal stem cells (MSCs) have revealed potential in small animal models, nonetheless consequencesin greater vertebrates have been varied.

Intervertevral Disc; Degeneration; Stem cells