Preparation and characterization of micro-bead vaccines for oral administration

  • سال انتشار: 1391
  • محل انتشار: دهمین سمینار بین المللی علوم و تکنولوژی پلیمر
  • کد COI اختصاصی: ISPST10_538
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 304
دانلود فایل این مقاله

نویسندگان

Golnaz Isapour Laskookalayeh

Department of Chemistry, University of Oslo, Oslo, Norway.

Atoosa Maleki

Department of Chemistry, University of Oslo, Oslo, Norway.

Lilia Ulanova

Department of Molecular Biosciences, University of Oslo, Oslo, Norway

Antje Hoenen

Department of Molecular Biosciences, University of Oslo, Oslo, Norway

چکیده

Vaccination is overall a promising approach to diseases because of its low frequency of side effects and its great preventative and therapeutic effects. Differently fromparenteral vaccination, which cannot induce mucosal immunological defense and is invasive and painful, oral and/or nasal vaccines elicit both systemic and mucosalimmunity and have a much higher patient’s compliance. Mucosally administered antigens are, however, poorlyimmunogenic and therefore the association of vaccine with nano or micro particulate carrier systems has been investigated and has shown that after oral administration the immuneresponse is elicited [l]. In this work, poly (D,L-lactic-co-glycolic acid) (PLGA), as a biocompatible and biodegradable polymer ,has been employedin the production of micro-carriers for encapsulation of Infectious Salmon Anemia (ISA) Virus. The micro-particlesthen incorporated with chitosan and alginate to produce large particles up to 1 mm. The particles can be used as vaccine against the most common virus in aquaculture of salmon

کلیدواژه ها

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.