Synthesis, Characterization and Micellization of Cholesteryl PLA-PEG Polymer Brushes as a Novel Drug Nano Carrier

The formation of polymeric micelles with high stability by the self-association of amphiphilic polymer brushesin aqueous medium is currently a topic of great interest [1].Poly L-lacticacid is a nontoxic biodegradable polymer and PEG is a nonimmunogenic nontoxic water-soluble polymer, which ishydrophilic and known to prevent interactions with proteins [2]. Herein, amphiphilic brush copolymers comprising hydrophobic cholesteryl-(L-lactic acid)n(CPLA) andhydrophilic polyethylene glycol (PEG) chains were used as a promising drug carrier. Biodegradable CPLA has beenincorporated into the core of micelles and hydrophilic outerlayer acts as a shelter to protect the inner hydrophobic core from being recognized and cleaned by the reticuloendothelial system (RES) and other clearing organs.