Synthesis and characterization of raloxifene hydrochloride-carboxylated polyurethane nanoparticles

Raloxifene hydrochloride is indicated for treatment and prevention of osteoporosis in postmenopausal women and reduction in the risk of invasive breast cancer inpostmenopausal women with osteoporosis and postmenopausal women at high risk of invasive breast cancer. It has low solubility in water with low bioavailability [1].Due to the great variety of raw materials that can be used in their formation, polyurethanes (PU) are probably the mostversatile class of polymers[2].Physical properties of polyurethanes (PUs) are changed with changing in average molar masses and molar mass distributions and can beimproved by incorporating hard segments with ionic group such as carboxylate group[3]. The polymer is not cytotoxic[4]. In this study carboxylated polyurethanes with different molecular weight were synthesized and applied as drug carriers of raloxifene hydrochloride to increase the bioavailability of the drug