Investigation of effect of various drug loading and addition of a rate modifying agent on famotidine release from in situ forming implants
- سال انتشار: 1393
- محل انتشار: یازدهمین سمینار بین المللی علوم و تکنولوژی پلیمر
- کد COI اختصاصی: ISPST11_672
- زبان مقاله: انگلیسی
- تعداد مشاهده: 273
نویسندگان
NDDS department, Iran Polymer and Petrochemical Institute, P.O.Box: 14965/115, Tehran, Iran
NDDS department, Iran Polymer and Petrochemical Institute, P.O.Box: 14965/115, Tehran, Iran
NDDS department, Iran Polymer and Petrochemical Institute, P.O.Box: 14965/115, Tehran, Iran
چکیده
In this study, effects of drug loading and a rate-modifying agent on in vitro famotidine release from injectable in situ forming implants were investigated. Implant formulations contain specific amount of solvent and polymer, but different drug loading (4%, 8% and 11%). For the preparation of the formulations, N-methyl-2-pyrrolidone (NMP) was used as solvent while poly(DL-lactide-co-glycolide) (Resomer RG 503) was used as polymer and after injection into an aqueous environment, NMP diffusion led to polymer precipitation and the formulation showed acceptable regular release of drug for 2 weeks. Results showed that the amount of drug released (47.63%) over the first 24 hours (burst phase) for 4% drug loading system, was significantly higher than that of 8% loading (40.11%) and 11% drug loading (32.18%).Addition of ethyl heptanoate as a rate-modifying agent also demonstrated a reduction in the burst release. This effect might be due to decreasing the exchange rate of solvent and nonsolventکلیدواژه ها
In situ forming implant- PLGA- drug loading- Ethyl heptanoate- Famotidineاطلاعات بیشتر در مورد COI
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