Cyclophosphamide Drug Release from Polyethylene Glycol Membranes Containing Water and Ethanol Solvents: Molecular Dynamic Simulations
عنوان مقاله: Cyclophosphamide Drug Release from Polyethylene Glycol Membranes Containing Water and Ethanol Solvents: Molecular Dynamic Simulations
شناسه ملی مقاله: ISPST11_583
منتشر شده در یازدهمین سمینار بین المللی علوم و تکنولوژی پلیمر در سال 1393
شناسه ملی مقاله: ISPST11_583
منتشر شده در یازدهمین سمینار بین المللی علوم و تکنولوژی پلیمر در سال 1393
مشخصات نویسندگان مقاله:
Zahra Shariatinia - Department of Chemistry, Amirkabir University of Technology (Polytechnic), P. O. Box: 159875-4413, Tehran, Iran.
خلاصه مقاله:
Zahra Shariatinia - Department of Chemistry, Amirkabir University of Technology (Polytechnic), P. O. Box: 159875-4413, Tehran, Iran.
Molecular dynamic (MD) simulations were applied to study the effect of solvents on the drug release from membranes consist of polyethylene glycol (PEG). Two different solvents including water and ethanol (100 molecules) were used as well as anticancer cyclophosphamide drug, five PEG chains each including ten repeating units in these simulations. The mean square displacement diagrams revealed that the drug mobility ishigher in the system made by ethanol
کلمات کلیدی: Molecular dynamic simulation, polyethylene glycol, cyclophosphamide, drug release
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/579148/