In Situ Prepared CuI Nanoparticles Immobilized on Modified Poly(styrene-co-maleic anhydride): An Efficient Recyclable Catalyst for Click Reaction

A high-yielding and facile methodology for the copper-catalyzed synthesis of 5-substituted 1H-terazoles in water is reported in the presence of copper nanoparticles (NPs) on modified poly(styrene-co-maleic anhydride) [SMA] catalyst. The polymer-support is easily prepared from the reaction of SMA with 4-aminopyridine, and subsequently undergoes to the reaction with in situ prepared CuI NPs. The catalyst was characterized by SEM, EDAX, FTIR and ICP and is applied for the preparation of terazoles under air, in good yield, and no chromatographic separation of the products. The catalyst can be used without pre-activation and reloaded for at least 5 runs without significant decrease in its activity.