pH-responsive and biodegradable PEG-PCL-PGA polymeric nano particle for oral macromolecules delivery

The PEG-PCL-PGA triblock copolymer was synthesized by ring-opening polymerization. Synthesized polymers were characterized and verified by FTIR, 1H NMR spectroscopy and GPC. Then carbocyclic acid groups were attached by Click chemistry to PEG-PCL-PGA. This amphiphlic triblock copolymer was self-assembled to nano structure in water. DLS studied indicated the formed nano structure have pH- responsive properties. This pH-responsive nano particle is good candidate for oral delivery of macromolecules such as peptide, heparin and insulin due to protective properties toward pH change