Aqueous Stability of Leuprolide Acetate: Effect of Temperature, Dissolved Oxygen, pH and Complexation with β-Cyclodextrin
- سال انتشار: 1393
- محل انتشار: یازدهمین سمینار بین المللی علوم و تکنولوژی پلیمر
- کد COI اختصاصی: ISPST11_198
- زبان مقاله: انگلیسی
- تعداد مشاهده: 408
نویسندگان
Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
Department of Novel Drug Delivery Systems, Iran Polymer and Petrochemical Institute, Tehran, Iran
Biomaterials Group, Materials and Energy Research Center, Tehran, Iran
چکیده
In the present research, the aqueous stability of leuprolide acetate (LA) in phosphate buffered saline (PBS) medium was studied. For this purpose, the effect of temperature, dissolved oxygen and pH on the stability of LA during 35 days was investigated. Results showed that the aqueous stability of LA was higher at low temperatures. Degassing of the PBS medium partially increased the stability of LA at 4 °C, while did not changed that at 37 °C. The degradation of LA was accelerated at lower pH values. In addition, complexes of LA with different portions of β-cyclodextrin (β-CD) were prepared through freeze-drying procedure. Studying their aqueous stability at various pH values showed LA/β-CD complexes exhibited higher stability in comparison to LA. The stability of complexes was also improved with increasing the portion of LA/β-CD up to 1/10کلیدواژه ها
leuprolide acetate - aqueous stability - β-cyclodextrin – HPLCاطلاعات بیشتر در مورد COI
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