Thermosensitive and Antibacterial Semi-Interpenetrating Polymer Network Based on Polyurethane and Poly(n-isopropylacrylamide) for Wound Dressing Application

This work is reporting preparation of novel thermoresponsive and antibacterial semi-interpenetrating polymer networks (semi-IPNs) composed of polyurethane/poly(n-isopropylacrylamide) via thermal radical initiated polymerization technique for potential use as wound dressing. Antiseptic performance of membranes was provided by incorporating silver particles formed by reduction of silver nitrate in semi-IPN hydrogels at room temperature. The temperature-dependent behavior of the semi-IPNs was studied by determining surface and bulk hydrophilicity. In addition, viscoelastic and physical properties of the prepared membranes were studied by dynamic mechanical thermal analysis (DMTA) and water vapor transition rate measurement. The results hold promise for application of these semi-IPNs as wound dressing membrane.

کلیدواژه ها:

Wound dressing ، Thermosensitive ، Antibacterial ، Polyurethane ، Poly(N-isopropylacrylamide)