Dexamethasone release from poly (lactic-glycolic acid) microparticles prepared by oil-in-oil emulsion solvent evaporation technique

An oil-in-oil emulsion solvent evaporation technique is introduced to produce particles containing corticosteroid anti-inflammatory dexamethasone for uveitis eye treatment in this study. Uveitis is the inflammation of the uvea which is a common ocular disease in the world. This study describes the effect of solvent, polymer, and drug loading on poly (D, L – lactic – co – glycolic acid) (PLGA) particles specifications. SEM was used for morphological investigations, and FTIR was investigated the chemical bonds. Also, Differential scanning calorimeter (DSC) was used to determine the physical state of encapsulated drug. Results demonstrated that the size of the PLGA microparticles prepared from acetonitrile was smaller than that from acetone. Drug released experiments indicate that this system possesses sustained release characteristics