Effect of γ-Irradiation on Leuprolide Acetate Release from PLGA-based In Situ Forming System
- سال انتشار: 1395
- محل انتشار: دوازدهمین سمینار بین المللی علوم و تکنولوژی پلیمر
- کد COI اختصاصی: ISPST12_024
- زبان مقاله: انگلیسی
- تعداد مشاهده: 503
نویسندگان
Department of Biomedical Engineering, Islamic Azad University, Tehran, Iran
Department of Novel Drug Delivery Systems, Iran Polymer and Petrochemical Institute, Tehran, Iran,
Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Tehran, Iran
Biomaterials Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, Karaj, Iran
چکیده
In this study, leuprolide acetate-loaded implants were prepared from PLGA-based in situ forming system and the effects of γ-irradiation on drug release profiles were investigated. PLGA-based in situ forming systems were prepared by injecting some specific amount of irradiated solution of PLGA /drug and NMP into a buffer phosphate pH 7.4 at 37 ºC. The effects of γ-ray on drug release profiles, morphology of matrices and their thermal properties were evaluated. Reduction of Tg and molecular weight of PLGA after irradiation due to radiolytic degradation such as random chain scissions effected the release drug profiles. The SEM images indicated that the irradiated samples had higher porosity than the non-irradiated sample therefore, drug release rate was increased.کلیدواژه ها
In situ forming systems- Poly(lactide-co-glycolide)- Leuprolide acetate- γ-Irradiation method- Drug delivery systemsاطلاعات بیشتر در مورد COI
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