Efficacy of Intrauterine infusion of granulocyte colony stimulating factor on patients with history of implantation failure: A randomized control trial
- سال انتشار: 1395
- محل انتشار: International Journal of Reproductive BioMedicine، دوره: 14، شماره: 11
- کد COI اختصاصی: JR_IJRM-14-11_002
- زبان مقاله: انگلیسی
- تعداد مشاهده: 402
نویسندگان
M.D.Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
M.D.Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran- Department of Obstetrics and Gynecology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
M.D. Department of Obstetrics and Gynecology, Endocrinology and Female Infertility Unit, Roointan Arash Women’s Health Research and Educational Hospital, Tehran University of Medical Sciences, Tehran, Iran.
M.D. Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
چکیده
Background: Although pregnancy rate in in vitro fertilization-embryo transfer (IVF-ET) cycles has been increased over the preceding years, but the majority of IVF-ET cycles still fail. Granulocyte colony stimulating factor (GCSF) is a glycoprotein that stimulates cytokine growth factor and induces immune system which may improve pregnancy rate in women with history of implantation failure.Objective: The aim of this study was to evaluate GCSF ability to improve pregnancy rate in women with history of implantation failureMaterials and Methods: 0.5 ml (300 μg/ml) GCSF was infused intrauterine in intervention group. Pregnancy outcomes were assessed based on clinical pregnancy.Results: The mean age of participants was 31.95±4.71 years old. There were no significant differences between demographic characteristics in two groups (p> 0.05). The pregnancy outcome in GCSF group was improved significantly (p=0.043).Conclusion: GCSF can improve pregnancy outcome in patients with history of implantation failure.کلیدواژه ها
GCSF, Pregnancy rate, In vitro fertilizationاطلاعات بیشتر در مورد COI
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