Synthesis of 1-benzyl-N'-benzylidenepiperidine-3-carbohydrazide Derivatives as New Antiplatelet Aggregation Agents

A strategy toward the synthesis of a series of aryl hydrazones substituted 1-benzylpiperidine-3-carboxylic acid derivatives , bearing various selected substituents on both the piperidine ring nitrogen and the hydrazide nitrogen, a class of compound with potential antiplatelet aggregation activity was developed. Aryl hydrazones derivatives of 1-benzylpiperidine-3-carboxylic acid were synthesized in five-step, starting from nicotinic acid and their anti platelet activity was assessed using human platelet rich plasma. The platelet concentrate was obtained using a two-step centrifugation protocol and ADP, arachidonic acid (AA) and collagen were used as inducers of platelet aggregation

کلیدواژه ها:

Nipecotic acid ، piperidine ، aryl hydrazone ، Antiplatelet ، platelet Aggregation