Thermal Induced Changes in Human Serum Albumin on Diabetic and Non Diabetic Conditions

There are various factors, which affect protein structure stability such as temperature, pH,inorganic salts, organic solvents, detergents, and pressure [1, 2]. However, among thesefactors, temperature is most important [3]. The thermal resistance of a protein is an importantproperty in biochemical and biomedical applications [4]. For most proteins, theconformational changes at the secondary structure such as increased β-sheet content may leadto formation of amyloid fibrils [5] The secondary structural protein are localized frequent thatfind proteins on the during folding. Secondary structure changes lead total changes in proteinthat causes disorders in protein function. In this study, the thermal effect on secondarystructural reversibility of human serum albumin (HSA) has been studied in diabetic and nondiabeticconditions.