Comparison of PAMAM dendrimer and dendrimer functionalized reduced graphene oxide modified pencil graphite electrodes for electrochemicaldetermination of anticancer drug

This study aims to comparison between the first generation poly (amidoamine) (PAMAM) dendrimer (G1) and dendrimer functionalized reduced graphene oxide (G1/rGO) to measure theanti-cancer drug using modified pencil graphite electrodes (PGEs). As new electrochemical sensors, modified PGEs were developed and used for monitoring rituximab (RTX) drug using differential pulse voltammetry (DPV), and cyclic voltammetry (CV). In so doing, for bothsensors, a well resolved reversible diffusion controlled voltammetric peak was obtained in phosphate buffer solution (pH=7). However, compared to the G1/PGE, the G1/rGO/PGE functioned far better in the drug detection. To obtain linear relationship between peak current andconcentration of rituximab, differential pulse voltammeter was applied and used for quantitative detection of rituximab drug in biological fluids. Linear response was obtained in the range of 0.0700 to 0.8340 μM with a detection limit of 0.0029 μM for G1/PGE and 0.0012 μM for G1/rGO/PGE.

کلیدواژه ها:

Rituximab ، Dendrimer ، Graphene oxide ، Differential pulse voltammetry