Determination of epinephrine using a carbone paste electrode modified with core shell nanocomposite and modifier

Epinephrine (EP), commonly called adrenaline, is one of the important catecholamine neurotransmitters in the mammalian central nervous system and plays a very important role in the function of the central nervous, hormonal, and cardiovascular systems. Many diseases are related to a change of catecholamine concentration, therefore it is necessary to develop quantitative methods for the determination of catecholamine concentration in order to study itsphysiological function and to be able to diagnose some diseases in the clinical medicine field [1]. The electrochemical methods using chemically modified electrodes (CMEs) have been widely used as sensitive and selective analytical methods for the detection of the trace amount ofbiologically important compounds [2].One of the most important properties of CMEs has been their ability to catalyze the electrode process via significant decreasing of overpotential respect to relatively selective interaction of the electron mediator with the target analyte in a coordination fashion. These electrodes are capable to considerably enhance the selectivity in the electroanalytical methods [3]. Some advantages of using themodified electrode are ease ofpreparation, low cost, potential window, ease modification, excellent electrical conductivity andincreasing the surface of the electrode [4]. In this work, a sensitive and selective electrochemical method for the determination of EP was developed using a modified carbon paste electrode(MCPE) with modifier andcore–shell magnetic nanoparticles. The electrochemical response characteristics of the modified electrode toward EP were investigated by cyclic and square wave voltammetry. It has been found that under optimum condition (pH 7.0) in cyclic voltammetry, the oxidation of epinephrine occurs at a potential about 100 mV less positive than that of an unmodified carbon paste electrode.

کلیدواژه ها:

Epinephrine ، Core–shell magnetic nanoparticle ، Electrocatalytic ، Carbon paste electrode ، Modifier