ATP-binding cassette (ABC) transporters as emerging targets in modulation of neural stem cells behavior in neurodegenerative diseases and cell therapy benefits
- سال انتشار: 1393
- محل انتشار: مجله سلول و تحقیقات مولکولی، دوره: 6، شماره: 1
- کد COI اختصاصی: JR_JCMR-6-1_002
- زبان مقاله: فارسی
- تعداد مشاهده: 464
نویسندگان
Central Laboratory for Stem Cells & translational Medicine, Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad, 500 058, Andhra Pradesh, India PAN Research Foundation, Narayanguda, Hyderabad, Andhra Prade
Central Laboratory for Stem Cells & translational Medicine, Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad, 500 058, Andhra Pradesh, India PAN Research Foundation, Narayanguda, Hyderabad, Andhra Prade
PAN Research Foundation, Narayanguda, Hyderabad, Andhra Pradesh, India
Central Laboratory for Stem Cells & translational Medicine, Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad, 500 058, Andhra Pradesh, India PAN Research Foundation, Narayanguda, Hyderabad, Andhra Prade
چکیده
Increasing incidence of central nervous system (CNS) disorders has become a major challenge for both basic and clinical scientific society to develop novel therapeutic models for treatment. The knowledge of stem cells has added anew dimension in the research towards finding more appropriate targets responsible for the disease fate determination.As stem cell research is progressing day by day in routine research laboratories there is great hope to find suitabletherapeutic targets for complete cure of the CNS disorders. Discovery of ABC transporters in animal tissues hasemerged as new spot for several disease prognosis and therapeutic target. ABC transporters are membrane proteins expressed in various organs like liver, kidney, blood-brain barrier, blood-testis barrier etc. It is involved in various important cellular processes such as absorption, distribution and excretion of drugs, xenobiotics and endogenouscompounds showing their role in tissue defense and organ regeneration. The current review explains about the role of ABC transporters in CNS pathogenesis and defense adding stem cells therapeutic strategies.کلیدواژه ها
ABC transporters; Neurodegenerative diseases; Stem cell therapyمقالات مرتبط جدید
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