Hosssein Aghamollaei - Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Seyed Latif Mousavi Gargari - Department of Biology, Faculty of Basic Science, Shahed University, Tehran Iran
Mostafa Ghanei - Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

Endoplasmic reticulum has a critical role in the synthesis and folding of secretory and membrane proteins. High accumulation of proteins in ER activates the unfoldedprotein response and glucose regulated protein 78 or GPR78 plays an essential role in this pathway. Unfolded protein response is activated in cancerous cellsdue to their adverse condition to survive and it has been shown that GRP78 can be expressed in tumor cell membrane. Overexpresion and localization of GRP78makes it a suitable target for the treatment of cancer. This review describes cellular localization, biological function, and role of GRP78 in cancer induction. Methods for tumor inhibition via GRP78 are also discussed.

GRP78, Biological Function, Cancer, Tumor