Evaluation of factor H linear and conformational epitopes on the Neisseria meningitidis

  • سال انتشار: 1395
  • محل انتشار: کنفرانس بین المللی پژوهش در علوم و مهندسی
  • کد COI اختصاصی: ICRSIE01_387
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 725
دانلود فایل این مقاله

نویسندگان

Navid Farahmandian

Departeman of biology, Science and Art University, Yazd, Iran

Ehsan Zareian Jahromi

Department of Biology, Biological Sciences, Kharazmi University, Tehran, Iran

Fateme SeFID

Department of Biology, shahed University ,Tehran-Qom Express Way

Sara khaleghizade

Biology department of yazd payamnoor university taft branch

چکیده

One of meningococci bacteria is Neisseria meningitidis which is a Gram-negative microorganism and an exclusive human pathogen. This bacterium usually exists in an asymptomatic nasopharyngeal carriage state. Following its penetration into the mucosal tissue, invasion of the bloodstream, and colonization of the meninges, this pathogen can cause devastating invasive disease, such as septicemia or meningitis. As the disease often progresses very rapidly, it is difficult to diagnose and treat(1,2). The associated mortality is about 10%, and permanent sequelae such as hearing impairment, mental retardation, or limb loss are common in survivors. Following the discovery and showing importance of the meningococcal factor H binding protein (fHBP) during the recent years two recombinant MnB vaccines have been developed which either are directed to fHBP as the single target of the vaccine or contain fHBP as one of the components. Binding of human factorH(hfH) by meningococci down regulates the host alternative complement pathway and helps the organism to evade host innate immunity. Nowadays, bioinformatics is reliably working in biology researches. It could be harnessed in vaccine plan as well as epitope mapping drives. In the present study we exploit bioinformatic tools to introduce the best regions of factor H binding protein (fHBP) as antigenic determinants in order to design (a) novel construct (s) as vaccine or diagnostics.

کلیدواژه ها

Neisseria meningitides, factorH(hfH), linear and conformational epitopes

مقالات مرتبط جدید

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.