Synthesize of amino alkyl naphthalen-2-ol derivatives usingLacl3.7H2O as highly efficient and reusable catalyst undersolvent-free condition

This study was designed to synthesize 1-(phenyl((5-phenyl-1,3,4-thiadiazol-2- yl)amino)methyl)naphthalen-2-ol derivatives as a new Schiff’s bases. An efficient and direct protocol for the preparation of aminoalkyl naphthols via a multi-component, onepotcondensation reaction of b-naphthol, aromatic aldehydes and 5-phenyl-1,3,4-thiadiazol-2-amines under solvent-free conditions has been described. This rout has some advantages such as solvent-free conditions, shorter reaction times, simple work-up, excellent yield, recovery and reusability of catalyst. It is noteworthy that 1-(phenyl((5-phenyl-1,3,4- thiadiazol-2- yl)amino)methyl)naphthalen-2-ols can be converted into important biological ‘drug like’ active compounds

کلیدواژه ها:

amioalkyl naphtol ، thiadiazol ، solvent-free conditions ، 2-naphtol ، MCRs