Evaluation of criteria for nasal drops and solutions containing sea-salt water regarding risk of pollution to the Lead and Cadmium

Introduction: Using natural ingredients in drug manufacturing is a common sense in recent pharmaceutical technology. Besides the advantages of these ingredients, they might be hazardous if used without proper knowledge about them. An important kind of hazard caused by these ingredients is tainted with a variety of pollutions. As an example, using sea salt in nasal drops and irrigation solutions is very common these days. Although sea salt can be beneficial, it can contain pollutions like heavy metal impurities. Heavy metal impurities, on top of it, impurity due to Lead and Cadmium can cause several damages like neurological disorders, immune defect, liver damages, cardiovascular disorders, osteoporosis, gene destruction and various types of cancer. To prevent these effects, nasal drops and irrigation solutions containing Sodium chloride, especially with natural sources, should have heavy metal ratio in proper limit states. To evaluate their ratio, according to the case under study, there exist different approaches. The solo purpose of this study is evaluation of nasal drops and solutions containing salt water and sea-salt regarding risk of pollution to Lead and Cadmium and comparing with national and international legislations. Materials and methods: Method employed in this study to evaluate heavy metal ratios is atomic absorption spectroscopy AA-670 model with the use of graphite oven. In the proposed method, after preparing standard and sample solutions, heavy metal ratio is evaluated using atomic absorption spectroscopy and the results were compared with standard regulations. Results and conclusion: By comparing the results of different samples with different salt concentrations, brands and source of salt, the amount of Lead and Cadmium varies significantly and sometimes violates the specified regulations. Among the experimented samples, the average for Lead concentration in irrigation solutions 11.40 ng/ml and Cadmium 1.8 ng/ml violate the standard level and in other samples of nasal drops and sprays the average of Lead and Cadmium concentration were in range.

کلیدواژه ها:

Nasal drops ، Irrigation solutions ، Heavy metal impurities ، Lead and Cadmium