Naringin inhibits tumor growth and useful for the treatment of cancer

Naringin, chemically 4',5,7-trihydroxyflavanone-7-rhamnoglucoside, is a major flavanone glycoside obtained from tomatoes, grape fruits, and many other citrus fruits. It has been experimentally documented to possess numerous biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. The purpose of this study was to explore the anticancer effect and mechanism of naringin. Our data demonstrated that, naringin inhibited cell proliferation, and promoted cell apoptosis and G1 cycle arrest, accompanied by increased p21 and decreased surviving. Based on comprehensive PubMed search for publications on these areas in naringin, we provided a review of what is known about the chemopreventive and anticancer attributes in various models of cancers, etiology, pathophysiology and clinical course and outcomes, and the search was conducted using the databases PubMed, Medline, EMBASE and Web of Science. Naringin has exerted chemopreventive and anticancer attributes in various models of oral, breast, colon, liver, lung, and ovarian cancer. Due to the scarcity of human studies on naringin, this review focuses on the various established activities of naringin in in vitro and in vivo preclinical models, and its potential therapeutic applications using the available knowledge in the literature. Additionally, it also encompasses the pharmacokinetic properties of naringin and its inhibition of CYP isoenzymes, and the subsequent drug interactions. Moreover, further clinical research is evidently needed to provide significant insights into the mechanisms underlying the effects of naringin in humans. The flavonoid naringin is a polyphenolic compound that naturally occurs in citrus. Patients with cancer generally present features of malnutrition and cachexia. Levels of the proinflammatory cytokines tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) are raised in patients with cancer. These results indicate that naringin could inhibit growth potential of TNBC cells, which suggests naringin might be used as a potential supplement for the prevention and treatment of breast cancer.

کلیدواژه ها:

Breast cancer ، Flavonoid naringin ، Chemopreventive ، Anticancer