Somayeh Behrouz - Medicinal Chemistry Research Laboratory, Department of Chemistry, Shiraz University of Technology,Shiraz 71555-313, Iran
Mohammad Navid Soltani Rad - Medicinal Chemistry Research Laboratory, Department of Chemistry, Shiraz University of Technology,Shiraz 71555-313, Iran
Bahare Taghavi Shahraki - Medicinal Chemistry Research Laboratory, Department of Chemistry, Shiraz University of Technology,Shiraz 71555-313, Iran

The design and synthesis of novel eugenol ether derivatives including β-hydroxypropyl-bonded azole frameworks as new analogs of β-adrenoceptor antagonists have been described. In this synthesis, the reaction of eugenol with epichlorohydrin afforded the corresponding eugenol ethers 13 and 14. Subsequently, the N-alkylation of several bioactive azoles with adducts 13 and 14 led to the desired eugenol derivatives 15 in good yields.

β-adrenoceptor antagonist, aryloxypropanolamine, azole, eugenol, eugenol ether