Natural Bioactie Compounds: Antibiotics

Nature acts as a prominent reservoir for novel therapeutic compounds. Antibiotics are powerful therapeutic agents that produced by diverse living organisms. Over the last several decades, natural products particularly antibiotics have continued to play a significant role in drug discovery and development process for developing drugs with high degree of therapeutic index and specific action. Today, there is an alarming deficiency of new antibiotics in the pharmaceutical industry that could be due to the emerging of antibiotic resistance of some pathogens, toxicity and undesirable side effects of some used antibiotics, although much progress has been performed in the field of chemical synthesis and engineered biosynthesis of antimicrobial compounds. Hence, today as part of the strategy to control the emerging drug-resistant pathogens in research programms around the world, there is a need approach for novel antibiotics and research to improve the safety as well as therapeutic efficiency of the discovered bioactive compounds. This article reviews the history of antibiotics, different types of antibiotics, mechanisms of antibiotic action and new challenges in antibiotics.

کلیدواژه ها:

Antibiotics ، natural bioactive compound ، secondary metabolites ، microorganisms ، Pharmaceutical industries