Voltammetric study of the influence of supporting electrolytes on the electrochemical behavior of tamoxifen as breast anticancer drug in aqueous medium and it’s extraction from tablets
- سال انتشار: 1394
- محل انتشار: دومین کنفرانس بین المللی علوم و مهندسی
- کد COI اختصاصی: ICESCON02_211
- زبان مقاله: انگلیسی
- تعداد مشاهده: 555
نویسندگان
Department of Chemistry, Faculty of Science, Islamic Azad University, Arak Branch
Department of Chemistry, Faculty of Science, Islamic Azad University,Omidiyeh Branch
Department of Chemistry, Faculty of Science, Islamic Azad University, Arak Branch
چکیده
In this work, the electrochemical behavior of tamoxifen as an anti cancer drug were investigated at a glassy carbon electrode (GCE) in Britton-Robinson (BR) buffer at different pH as well as in H2SO4. H2SO4 was the best supporting electrolyte in this work. Cyclic voltammetry (CV) and chronoamperometry were used to understand the electrochemical characteristics of tamoxifen (Tam). Based on the results of the recorded CV, the electrodeposition and anodic striping behavior of the Tam were investigated at the surface of GCE. To find the best conditions for taking a sharp analytical peak concerning the electro-oxidation of Tam, differential pulse anodic adsorptive striping voltammetry (DPAASV) was studied. The primary experiments demonstrated that the DPAASV presents a sufficient oxidation peak current at approximately 1.03 V vs Ag/AgCl. Therefore, the effects of different parameters such as deposition potential, deposition time and concentration of H2SO4 have been studied and optimized. The obtained results shown that the -1.4 V, 30s and H2SO4 0.5 M are the optimal values, respectively. Then the calibration curve was plotted in the range of 0.5 to 80 μM and the limits of detection (LOD) and quantitation (LOQ) were calculated to be 0.12 and 0.4 μM, respectively. The mean, standard error and relative standard deviation (RSD) for 4 replicates of 15 μM were found to be 15.57 μM, 3% and 4%, respectively. To estimate the application potential of the proposed method, the extraction of Tam from tablets containing 20 mg Tam were investigated and optimized. Finally, the proposed method was successfully employed for determination of Tam in spiked physiological samples.کلیدواژه ها
Tamoxifen; DPAASV; Striping voltammetry; depositionاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.