Susceptibility Evaluation of Aspergillus fumigatus to Silver Nanoparticles Compared with Voriconazole
- سال انتشار: 1395
- محل انتشار: فصلنامه عفونت، اپیدمیولوژی و پزشکی، دوره: 2، شماره: 3
- کد COI اختصاصی: JR_IEM-2-3_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 615
نویسندگان
Department of Medical Mycology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IR Iran
Department of Medical Mycology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IR Iran
Department of Parasitology and Mycology, School of Medical Sciences, Iran University of Medical Sciences, Tehran, IR Iran
Department of Medical Mycology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IR Iran
چکیده
Background: This study was performed to determine antifungal activity of silver nanoparticles (nano-Ag) compared to voriconazole on clinical and standard strains of Aspergillus fumigatus. Materials and Methods: Inhibitory potency of nano-Ag was determined using microtiter broth dilution method. Susceptibility tests wereperformed against A. fumigatus isolated from BAL (bronchoalveolar lavage) of patients who suffered from respiratory problems andcompared with the strain (ATCC: 204305) by broth dilution antifungal susceptibility test of filamentous fungi approved by the Clinical and Laboratory Standards Institute M38-A. In addition, cytotoxicity effect of silver nanoparticles was studied on epithelial cell line by MTT assay. Results: From 60 BAL samples the following strains were isolated; A. flavus (n=21), A. niger (n=3), and A. fumigatus (n=1). The minimum inhibitory concentration (MIC90) values of nano-Ag were 0.25 and 0.5کلیدواژه ها
Aspergillus fumigatus, Silver nanoparticles, Cytotoxicityمقالات مرتبط جدید
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