Effect of vaginal misoprostol on pregnancy rate after intrauterine insemination: a randomized controlled trial
- سال انتشار: 1394
- محل انتشار: International Journal of Reproductive BioMedicine، دوره: 13، شماره: 1
- کد COI اختصاصی: JR_IJRM-13-1_002
- زبان مقاله: انگلیسی
- تعداد مشاهده: 472
نویسندگان
Reproductive Health Research Center, Department of Obstetrics and Gynecology, Guilan University of Medical Sciences, Rasht, Iran.
Reproductive Health Research Center, Department of Obstetrics and Gynecology, Guilan University of Medical Sciences, Rasht, Iran.
Reproductive Health Research Center, Department of Obstetrics and Gynecology, Guilan University of Medical Sciences, Rasht, Iran.
چکیده
Background: Intrauterine insemination (IUI) is one of the most appropriate and cost-effective methods in infertility treatment. Objective: We aimed to investigate effect of vaginal misoprostol on pregnancy rateafter IUI. Materials and Methods: Two hundred and ten infertile women who were referredto Infertility Clinic of Alzahra Hospital by an indication of IUI during 2012-2013 were randomly assigned to receive 200 μg vaginal misoprostol (n=105) or vaginalplacebo (n=105) after IUI. For detecting pregnancy, past 2 weeks, beta human chorionic gonadotropin evaluation was made and if positive, transvaginalsonography was done for evaluation of pregnancy 2-3 weeks later and clinical pregnancy was recorded.Results: Pregnancy had been noted in 24 patients in misoprotol (22.9%) and 27patients in placebo (25.7%) groups that this difference was not significant (p=0.748).In misoprostol group, 3 case of nausea and vomiting (2.9%) had been observed. Conclusion: According to the results, administering 200 μg vaginal misoprostol after IUI doesn’t have significant effect on the success rate of IUI.کلیدواژه ها
Misoprostol, Pregnancy, Intrauterine insemination, Randomized clinical trialاطلاعات بیشتر در مورد COI
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