Nasrin Ghasemi - Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Fatemehsadat Amjadi - Department of Anatomy, Tehran University of Medical Sciences, Tehran, Iran
Ensieh Salehi - Department of Anatomy, Tehran University of Medical Sciences, Tehran, Iran
Mojgan Shakeri - Tehran Islamic Azad University of Medical Sciences, Tehran, Iran

Background: The human female reproductive tract (FRT) is constantly deal with the invading pathogens. Recognition of these pathogens is attributed to the family of Toll like receptors (TLR) as a major part of the innate immune system. We and others have previously revealed that TLRs1-6 express in the female reproductive tract. However, more studies should be done to detect TLRs 7-10 in the female reproductive tract, especially in the fallopian tubes.Objective: To examine the expression of TLRs7-10 in human fallopian tube tissue.Materials and Methods: Using immunostaining techniques, distribution of TLR7-10 was studied in surgical sections from the uterine tubes, obtained from patients undergoing tubal ligation and hysterectomy for benign gynecological conditions. RT-PCR was used to show the existence of TLR7-10 genes in fallopian tube tissue.Results: TLR7-10 proteins were detected in the fallopian tube epithelium, although the intensity of staining was not equal in cases. TLR7-10 genes were expressed in human fallopian tube tissue.Conclusion: This study indicates that TLR7-10 is expressed in fallopian tubes tissues, and may play an important role in microbial recognition, and in host defense against ascending infection.

Fallopian tube, Innate immunity, Toll like receptors (TLRs), Reproductive medicine