Expression of Toll-like receptors 7-10 in human fallopian tubes
عنوان مقاله: Expression of Toll-like receptors 7-10 in human fallopian tubes
شناسه ملی مقاله: JR_IJRM-12-6_003
منتشر شده در شماره ۶ دوره ۱۲ فصل June در سال 1393
شناسه ملی مقاله: JR_IJRM-12-6_003
منتشر شده در شماره ۶ دوره ۱۲ فصل June در سال 1393
مشخصات نویسندگان مقاله:
Nasrin Ghasemi - Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Fatemehsadat Amjadi - Department of Anatomy, Tehran University of Medical Sciences, Tehran, Iran
Ensieh Salehi - Department of Anatomy, Tehran University of Medical Sciences, Tehran, Iran
Mojgan Shakeri - Tehran Islamic Azad University of Medical Sciences, Tehran, Iran
خلاصه مقاله:
Nasrin Ghasemi - Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Fatemehsadat Amjadi - Department of Anatomy, Tehran University of Medical Sciences, Tehran, Iran
Ensieh Salehi - Department of Anatomy, Tehran University of Medical Sciences, Tehran, Iran
Mojgan Shakeri - Tehran Islamic Azad University of Medical Sciences, Tehran, Iran
Background: The human female reproductive tract (FRT) is constantly deal with the invading pathogens. Recognition of these pathogens is attributed to the family of Toll like receptors (TLR) as a major part of the innate immune system. We and others have previously revealed that TLRs1-6 express in the female reproductive tract. However, more studies should be done to detect TLRs 7-10 in the female reproductive tract, especially in the fallopian tubes.Objective: To examine the expression of TLRs7-10 in human fallopian tube tissue.Materials and Methods: Using immunostaining techniques, distribution of TLR7-10 was studied in surgical sections from the uterine tubes, obtained from patients undergoing tubal ligation and hysterectomy for benign gynecological conditions. RT-PCR was used to show the existence of TLR7-10 genes in fallopian tube tissue.Results: TLR7-10 proteins were detected in the fallopian tube epithelium, although the intensity of staining was not equal in cases. TLR7-10 genes were expressed in human fallopian tube tissue.Conclusion: This study indicates that TLR7-10 is expressed in fallopian tubes tissues, and may play an important role in microbial recognition, and in host defense against ascending infection.
کلمات کلیدی: Fallopian tube, Innate immunity, Toll like receptors (TLRs), Reproductive medicine
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/489022/