Identification of Xq22.1-23 as a region linked with hereditary recurrent spontaneous abortion in a family
- سال انتشار: 1392
- محل انتشار: International Journal of Reproductive BioMedicine، دوره: 11، شماره: 8
- کد COI اختصاصی: JR_IJRM-11-8_009
- زبان مقاله: انگلیسی
- تعداد مشاهده: 545
نویسندگان
Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammad Hasanzadeh Nazar-Abadi
Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Background: Recurrent spontaneous abortion (RSA) is one of the most common health complications with a strong genetic component. Several genetic disorders were identified as etiological factors of hereditary X linked RSA. However, more genetic factors remain to be identified. Objective: In this study we performed linkage analysis on a large X linked RSA pedigree to find a novel susceptibility locus for RSA. Materials and Methods: A linkage scan using 11 microsatellites was performed in 27 members of a large pedigree of hereditary X-linked RSA. Two point parametric Linkage was performed using Superlink v 1.6 program. Results: Evidence of linkage was observed to markers at Xq23, DXS7133 and at Xq22.1 DXS101, with LOD score of 3.12 and 1.60, respectively. Conclusion: Identified locus in this study may carry a responsible gene in RSA. Narrowing down of this region may leads to identification of this geneکلیدواژه ها
X-linked, Recurrent spontaneous abortion, Linkageاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.