Comparison of recombinant human follicle stimulating hormone (rhFSH), human chorionic gonadotropin (HCG) and human menopausal gonadotropin (HMG) on semen parameters after varicocelectomy: a randomized clinical trial

  • سال انتشار: 1391
  • محل انتشار: International Journal of Reproductive BioMedicine، دوره: 10، شماره: 5
  • کد COI اختصاصی: JR_IJRM-10-5_007
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 576
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نویسندگان

Mohammad Ali Amirzargar

Department of Urology, Hamadan University of Medical Sciences, Hamadan, Iran

Mahnaz Yavangi

Department of Obstetrics and Gynecology, Fatemieh Infertility Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

Abbass Basiri

Urology and Nephrology Research Center, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Sayyed Mahdi Hosseini Moghaddam

Urology and Nephrology Research Center, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

چکیده

Background: The most frequent physical finding in infertile men is varicocele, in which one of the mechanisms that can affect seminal parameters is oxidative stress.Objective: Our study aimed, for the first time, to compare the efficacy of recombinant human follicle-stimulating hormone (rhFSH), human chorionicgonadotropin (HCG) and human menopausal gonadotropin (HMG) on sperm parameters and fertility after varicocelectomy. Materials and Methods: 113 infertile men with varicocele were divided into four groups. Group A received HCG 5000 IU weekly, group B received HMG 75 IUthree times a week, group C received rhFSH 75 IU three times a week and group D received no medical treatment after varicocelectomy.Results: After three months, in group A sperm morphology improved (p=0.007), causing a 32% pregnancy rate. In group B, sperm motility (p=0.023) andmorphology (p=0.014) improved, causing a 57% pregnancy rate. In group C, all of the investigated semen parameters increased (p< 0.05), causing a 62.5% pregnancyrate. Only rhFSH improved sperm concentrations to > 20×106 mL (p=0.027). In group D, sperm morphology increased (p=0.038), but other parameters remainedunchanged and no pregnancies occurred. Conclusion: It can be concluded that drugs can reduce induction time forspermatogenesis and fertility in comparison with varicocelectomy alone. For these purposes, rhFSH is more effective than other drugs

کلیدواژه ها

Male Infertility, Semen Analyses, Varicocele, Varicocelectomy, HCG, HMG,rhFSH

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