Analysis of 232 total fertilization failure cycles during intracytoplasmic sperm injection

سال انتشار: 1390
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 330

فایل این مقاله در 8 صفحه با فرمت PDF قابل دریافت می باشد

این مقاله در بخشهای موضوعی زیر دسته بندی شده است:

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

JR_IJRM-9-2_008

تاریخ نمایه سازی: 16 شهریور 1395

چکیده مقاله:

Background: The intracytoplasmic sperm injection procedure ending with total fertilization failure is very distressfull event for both the clinician and the patient.Objective: The aim of this study was to identify independent factors which could be used to identify total fertilization failure before the day of intracytoplasmic sperm injection.Materials and Methods: This was a retrospective study of 232 patients who were admitted to a tertiary-care hospital IVF Unit and showed total fertilization failure during intracytoplasmic sperm injection cycles. To sort out the interwined effects of female age, basal FSH, sperm quality, antral follicle count, starting dose of gonadotrophine, sperm extraction technique, cycle length, >14 mm follicle number, oocyte number after oocyte pick up, estradiol and progesterone level on the day of hCG and the MI, MII and GV oocyte number on the fertilization, multiple logistic regression analysis was used.Results: The total fertilization failure rate was 6% and the recurrance rate was 23%. The original model illustrated that the presence of GV oocytes, total oocyte number less than six, <2000 pg/mL E2 concentration on the day of hCG and testicular sperm extraction increases the total fertilization failure risk.Conclusion: It is very difficult to predict total fertilization failure. Sometimes even with one good quality oocyte and sperm and in the case of globozoospermia fertilization can be achieved. Not only azoospermia but also low oocyte numbers increase the chance of total fertilization failure even after intracytoplasmic sperm injection.

نویسندگان

Esma Sarikaya

Centre for Reproductive Medicine, Zekai Tahir Burak Women's Health Research and Education Hospital,Ankara, Turkey

Ozlem Gun Eryilmaz

Centre for Reproductive Medicine, Zekai Tahir Burak Women's Health Research and Education Hospital,Ankara, Turkey

Ruya Deveer

Centre for Reproductive Medicine, Zekai Tahir Burak Women's Health Research and Education Hospital,Ankara, Turkey

Muammer Dogan

Centre for Reproductive Medicine, Zekai Tahir Burak Women's Health Research and Education Hospital,Ankara, Turkey