Comparison of Prooxidant-antioxidant Balance between Patients with High Grade Gliomas (IV) and Control Group

  • سال انتشار: 1394
  • محل انتشار: مجله جراحی مغز و اعصاب ایران، دوره: 1، شماره: 2
  • کد COI اختصاصی: JR_IJN-1-2_004
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 673
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نویسندگان

Elnaz Farajirad

Head of Ghaem Health Center, Mashhad University of Medical Sciences, Mashhad, Iran

Kazem Ghaemi

Associate Professor of Neurosurgery, Head of Neurosurgery Department, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran

Mehdi Khajavi

Resident of Neurosurgery, Neurosurgery Department, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Daryoush Hamidi Alamdari

Stem Cell and Regenerative Medicine Research Group, Biochemistry & Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

چکیده

Background & Aim: The most common primary brain tumors of the central nervous system are gliomas. Among anumber of different biomolecular events, a strong relation between oxidative stress pathways and the developmentof this cancer has been proved. Oxidative stress (OS) is the consequence of an imbalance between pro-oxidantsand antioxidants towards pro-oxidants. The pro-oxidants cause lipid peroxidation of cell membranes, protein, DNAoxidation and changes in brain cell growth. In this study, the pro-oxidant–antioxidant balance (PAB) was determinedin patients with gliomas.Methods & Materials/Patients: Sera of 49 patients with high grade glioma (grade IV WHO) which is calledglioblastoma multiform (GBM) and 49 healthy subjects were collected and PAB test was measured.Results: A significant increase of PAB value was observed in patients with GBM (158.10±85.71 HK unit) in comparisonto control group (74.54±33.54 HK).Conclusion: The PAB assay showed the oxidative stress in glioblastoma. In further research, this easy elucidation ofoxidative stress in these patients can be applied to evaluate the effectiveness of antioxidant therapies in patients withGBM.K

کلیدواژه ها

Prooxidant-antioxidant; Balance; High Grade Gliomas

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