Facile Synthesis of 5-Substituted 1H-Tetrazoles Utilizing Doped Nano-Sized Copper(I) Oxide (Cu2O) on Melamine-Formaldehyde Resin

سال انتشار: 1395
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 472

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شناسه ملی سند علمی:

CHCONF02_607

تاریخ نمایه سازی: 9 مرداد 1395

چکیده مقاله:

An efficient and facile method for the synthesis of 5-substituted 1H-tetrazoles from structurally diverse nitriles and sodium azide is described using doped nano-sized copper(I) oxide (Cu2O) on melamine-formaldehyde resin (nano Cu2O-MFR) as a recoverable and reusable heterogeneous nano catalyst. A wide variety of nitriles underwent [3+2] cycloaddition with NaN3 under mild reaction conditions to afford the corresponding tetrazoles in good to excellent yields. Nano Cu2O-MFR was characterized by different microscopic, spectroscopic and physical techniques. The catalyst was easily separated and reused for five times without significant loss of its catalytic reactivity.

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نویسندگان

Somayeh Behrouz

Medicinal Chemistry Research Laboratory, Department of Chemistry, Shiraz University of Technology, ۷۱۵۵۵‑۳۱۳ Shiraz, Iran

Mohammad Navid Soltani Rad

Medicinal Chemistry Research Laboratory, Department of Chemistry, Shiraz University of Technology, ۷۱۵۵۵‑۳۱۳ Shiraz, Iran