Adeleh Ghasemi - Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran
Haleh Sameishoar - Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran

Aza heterocyclic compounds are major interest for organic chemists because of their mainly pharmacological activities and clinical applications such as antianxiety, antitumor, anticonvulsant, cardiotonic and vasorelaxant. This work a new and efficient synthesis of phthalazine drivatives from the three-component condensation reaction of malononitrile, phthalhydrazide and aromatic aldehydes using MCM-41 as catalyst. The features of this procedure are mild reaction conditions, good to excellent yields, short reaction times and operational simplicity.

MCM-41, Phthalazine, Malononitrile, Multi Component, Aza Hetrocyclic