Review on Pharmacological Investigations of Nigella Sativa in Animal Model

Herbs are vital source of drugs from the ancient time holding the scenario of the Indian system of medicine. Nigella sativacommonly known as karayal is an annual floweringplant, native to southwest Asia.Nigella sativa (NS) seed has been an important nutritional flavoring agent and natural remedy for many ailments for centuries in ancient systems of medicine, e.g. Unani, Ayurveda, Chinese and Arabic Medicines. Many active components have been isolated from N. sativa, including thymoquinone, thymohydroquinone, dithymoquinone, thymol, carvacrol, nigellimine-N-oxide, nigellicine, nigellidine and alpha-hederin. In addition, quite a few pharmacological effects of N. sativa seed, its oil, various extracts and active components have been identified to include immune stimulation, anti-inflammation, hypoglycemic, antihypertensive, antiasthmatic, antimicrobial, antiparasitic, antioxidant and anticancer effects.The present review is therefore, an effort to give a detailed survey of the literature of this herb on animal model.

کلیدواژه ها:

nigella sativa ، karayal ، seeds ، medicine