Interferon Resistance of Hepatitis C Virus Genotypes 1a/1b: Relationship to Nonstructural 5A Gene Quasispecies Mutations
عنوان مقاله: Interferon Resistance of Hepatitis C Virus Genotypes 1a/1b: Relationship to Nonstructural 5A Gene Quasispecies Mutations
شناسه ملی مقاله: NBCI04_239
منتشر شده در چهارمین همایش ملی بیوتکنولوژی ایران در سال 1384
شناسه ملی مقاله: NBCI04_239
منتشر شده در چهارمین همایش ملی بیوتکنولوژی ایران در سال 1384
مشخصات نویسندگان مقاله:
T Hashempour - Tarbiat Modares university, Faculty of Medical sciences, Department of virology
S Amini-Bovil-Olyaee - Biotechnology Department, Pasteur Institute of Iran, Tehran
M Karimi - Biotechnology Department, Pasteur Institute of Iran, Tehran
F Behzadian - Tarbiat Modares university, Faculty of Medical sciences, Department of virology
خلاصه مقاله:
T Hashempour - Tarbiat Modares university, Faculty of Medical sciences, Department of virology
S Amini-Bovil-Olyaee - Biotechnology Department, Pasteur Institute of Iran, Tehran
M Karimi - Biotechnology Department, Pasteur Institute of Iran, Tehran
F Behzadian - Tarbiat Modares university, Faculty of Medical sciences, Department of virology
Recently, the Nonstructural 5A protein of hepatitis C virus (HCV) was reported to interact with double stranded RNA-dependent protein kinase (PKR) through PKR binding domain and its target, eukaryotic translation initiation factor (eIF) 2α. Inhibition of the kinase activity of PKR by this interaction was postulated as a mechanism for the resistance to interferon (IFN) therapy. The aim of this study was to examine this issue in a series of patients with long-term response to IFN treatment.The patients were defined as long-term responders since they showed persisting biochemical and virological reaponse to IFN treatment.
کلمات کلیدی: C virus, Nonstructural 5A gene, Polymerase chain reaction, Interferon
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/45310/