An experimental study of the systemic alteration of nitroimidazoles in the middle stage of embryonic development
- سال انتشار: 1393
- محل انتشار: مجله بین المللی تحقیقات پیشرفته زیست شناختی و زیست پزشکی، دوره: 2، شماره: 5
- کد COI اختصاصی: JR_IJABBR-2-5_016
- زبان مقاله: انگلیسی
- تعداد مشاهده: 630
نویسندگان
Graduate student, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
Department of Avian Medicine, School of Veterinary Medicine, Shahid Bahonar University of Kerman,Kerman, Iran
Center of comparative&experimental medicine, Basic sciences in infection diseases research center, School of medicine, Shiraz University of Medical Sciences, Shiraz, Iran
School of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran
چکیده
Nitroimidazole compounds have been traditionally used in the veterinary and human medicine, but their uses are sometimes associated with some side effects. Toxicopathological effects of nitroimidazoles have always been a major concern. There is scant information available about thepathological alterations of nitroimidazole compounds in the embryo. The objective of this study was todetermine the macroscopic and microscopic lesions of metronidazole in the chicken embryo. Fertilebroiler eggs were divided into two equal treatment groups as follows: group 1: saline- injected group, the eggs were injected with sterile physiological saline solution into the chorioallantoic sac. Group 2, individuals were injected with metronidazole at a dosage of 25 mg/Kg egg-weight three times into the chorioallantoic sac. Macroscopically, the embryos were stunted. The feet and wings were small and thefeather formation was seriously affected. In this group, the embryos were affected by schistosomus reflexus. Microscopically, all organs were hyperemic. Based on macroscopic and microscopic findings, it is concluded that metronidazole at the above-mentioned concentration is toxic to thechicken embryo. The current study also advises caution in the extended use of nitroimidazole compounds.کلیدواژه ها
Chicken, Egg, Embryo, Metronidazole, Toxicopathologyمقالات مرتبط جدید
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.